2-Nitrobenzoyl chloride → 2,4-Pentanedione, 3-(2-nitrobenzoyl)-

반응식

[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7])([O-:3])=[O:2].C[Si](C)(C)[O:15][C:16]([CH3:21])=[CH:17][C:18](=[O:20])[CH3:19]>>[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([CH:17]([C:18](=[O:20])[CH3:19])[C:16](=[O:15])[CH3:21])=[O:7])([O-:3])=[O:2]

참가 물질

반응물 2

HCID 118752-Nitrobenzoyl chloride

HCID 1146323-Penten-2-one, 4-[(trimethylsilyl)oxy]-

생성물 1

HCID 51248932,4-Pentanedione, 3-(2-nitrobenzoyl)-수율 21.3%

반응 조건

온도: 140 °C

실험 절차

A mixture of 2-nitrobenzoyl chloride (500 mg) with 4-trimethylsilanyloxy-pent-3-en-2-one (540 mg) was stirred at 140° C. for 5 min. The reaction solution was cooled to room temperature and was then purified by column chromatography using acetone-hexane to give 3-(2-nitro-benzoyl)-pentane-2,4-dione (143 mg, yield 20%).

후처리

temperatureThe reaction solution was cooled to room temperature
customwas then purified by column chromatography

출처 및 근거

ORD 기록: ord-141acb8f0a9d4265ae32e57ce7935bac
출처 데이터셋: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07560558B2

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