Water → 2-chloro-N-(2-formylphenyl)acetamide

HRID 228842

반응식

HRID 228842 반응식
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[Cl:10][CH2:11][C:12](Cl)=[O:13].O>ClCCl>[Cl:10][CH2:11][C:12]([NH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5])=[O:13]

참가 물질

5

반응물 3

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 682552-Aminobenzaldehyde

생성물 1

HCID 125333492-chloro-N-(2-formylphenyl)acetamide수율 99%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Aminobenzaldehyde (650 mg) was dissolved in dichloromethane (20 ml) to prepare a solution. Chloroacetyl chloride (728 mg) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added thereto, and the mixture was extracted with dichloromethane. The dichloromethane layer was washed with water and saturated brine and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography using chloroform to give 2-chloro-N-(2-formylphenyl)-acetamide (1.05 g, yield 99%).

후처리

  1. customto prepare a solution
  2. extractionthe mixture was extracted with dichloromethane
  3. washThe dichloromethane layer was washed with water and saturated brine
  4. dry with materialwas dried over anhydrous sodium sulfate
  5. customThe solvent was removed by distillation under the reduced pressure
  6. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-7253859b6f0a4d0b8d00265a83cf1321
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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