Sodium methanethiolate → 6-Isoquinolinol, 7-methyl- (9CI)

HRID 228875

반응식

HRID 228875 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[CH:9]=[N:8][CH:7]=[CH:6]2.C[S-].[Na+]>CN(C)C=O>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[CH3:13])[CH:9]=[N:8][CH:7]=[CH:6]2

참가 물질

4

반응물 2

HCID 4378561Sodium methanethiolateHCID 230784386-Methoxy-7-methylisoquinoline

생성물 1

HCID 1357421666-Isoquinolinol, 7-methyl- (9CI)수율 9.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
160 °C

실험 절차

6-Methoxy-7-methylisoquinoline (239 mg) and sodium thiomethoxide (1.58 g) were suspended in N,N-dimethylformamide (12 ml), and the suspension was stirred at 160° C. for 2 hr. The reaction solution was cooled to room temperature, the reaction solution was then filtered, and the solvent was removed from the filtrate by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give 6-hydroxy-7-methylisoquinoline (21 mg, yield 1%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. filtrationthe reaction solution was then filtered
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure
  4. customThe residue was purified by thin layer chromatography

출처 및 근거

ORD 기록
ord-59963b43ab36432bae428be123756b9a
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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