Sodium methanethiolate → 6-Isoquinolinol, 7-bromo-

HRID 228878노트

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HRID 228878 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][C:3]=1[O:12]C.C[S-].[Na+]>CN(C)C=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[CH:9]2)=[CH:4][C:3]=1[OH:12]

참가 물질

4

반응물 2

HCID 4378561Sodium methanethiolateHCID 230784917-Bromo-6-methoxyisoquinoline

생성물 1

HCID 1358548376-Isoquinolinol, 7-bromo-수율 23.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
150 °C

실험 절차

7-Bromo-6-methoxyisoquinoline (50 mg) and sodium thiomethoxide (147 mg) were suspended in N,N-dimethylformamide (2 ml), and the suspensioin was stirred at 150° C. for 2 hr. The reaction solution was cooled to room temperature, the reaction solution was then filtered, and the solvent was removed from the filtrate by distillation under the reduced pressure. The residue was purified by thin layer chromatography using chloroform-methanol to give 7-bromo-6-hydroxyisoquinoline (11 mg, yield 22%).

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. filtrationthe reaction solution was then filtered
  3. customthe solvent was removed from the filtrate by distillation under the reduced pressure
  4. customThe residue was purified by thin layer chromatography

출처 및 근거

ORD 기록
ord-79cd1e5009574c81aaab3218a78ba9d0
출처 데이터셋
uspto-grants-2009_07
특허 번호
US07560558B2

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