Trifluoroacetic acid → HCID 178521336, 화합물

HRID 2289081노트

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HRID 2289081 반응식
[N+:1]([C:4]1[CH:46]=[CH:45][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:31][C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][C:39]([N+:42]([O-:44])=[O:43])=[CH:38][CH:37]=2)=[O:33])[NH:14][CH2:15][C:16]([NH:18][C@H:19]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2].[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50]>ClCCl>[F:47][C:48]([F:53])([F:52])[C:49]([OH:51])=[O:50].[N+:1]([C:4]1[CH:46]=[CH:45][C:7]([CH2:8][O:9][C:10]([N:12]=[C:13]([NH:31][C:32]([O:34][CH2:35][C:36]2[CH:37]=[CH:38][C:39]([N+:42]([O-:44])=[O:43])=[CH:40][CH:41]=2)=[O:33])[NH:14][CH2:15][C:16]([NH:18][C@H:19]2[CH2:23][CH2:22][NH:21][CH2:20]2)=[O:17])=[O:11])=[CH:6][CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178452035HCID 178452035, 화합물

생성물 1

HCID 178521336HCID 178521336, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of the compound (7.82 g), which had been obtained in (1), in anhydrous dichloromethane (10 ml), trifluoroacetic acid (5 ml) was added dropwise under ice cooling, followed by stirring for 4 hours. The reaction mixture was concentrated by evaporation under reduced pressure. The residue was washed with hexane-ether and the solvent was distilled off, whereby 1.00 g of the title compound was obtained. The product was provided for use in the subsequent reaction without purification.

후처리

  1. concentrationThe reaction mixture was concentrated by evaporation under reduced pressure
  2. washThe residue was washed with hexane-ether
  3. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-97b5ef9061d64991b409317030bfe578
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06090802

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