Dimethylformamide → 4-(2-chloroethoxy)benzoyl Chloride

HRID 2289157노트

반응식

HRID 2289157 반응식
[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9](O)=[O:10])=[CH:7][CH:6]=1.CN(C)C=O.C(Cl)(=O)C([Cl:22])=O>ClCCCl>[Cl:1][CH2:2][CH2:3][O:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([Cl:22])=[O:10])=[CH:7][CH:6]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 123892684-(2-Chloroethoxy)benzoic acid

생성물 1

HCID 110748714-(2-chloroethoxy)benzoyl Chloride

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

In a 250-ml flask are combined 4-(2-chloroethoxy)benzoic acid (2.58 g, 12.9 mmol), dimethylformamide (0.2 ml) and 1,2-dichloroethane (50 ml). Oxalyl chloride (1.35 ml) is added dropwise and the reaction mixture stirred overnight at room temperature. The reaction becomes homogeneous after stirring several hours. After an overnight stir, the solvent is evaporated to dryness, and the solid product is redissolved in 1,2-dichloroethane (2×50 mL) and evaporated. The product is used as is in subsequent reactions.

후처리

  1. customIn a 250-ml flask are combined
  2. stirringafter stirring several hours
  3. stirringAfter an overnight stir
  4. customthe solvent is evaporated to dryness
  5. dissolutionthe solid product is redissolved in 1,2-dichloroethane (2×50 mL)
  6. customevaporated

출처 및 근거

ORD 기록
ord-865766fccdd6458aa3d514b217c001c8
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06090949

반응 노트

불러오는 중…