Tetrahydrofuran → 4-n-Butylidene-4,5,6,7-tetrahydrobenzo[b]furan

참여 물질

역할	이름	HCID	투입량
반응물	Tetrahydrofuran	HCID 8028	—
반응물	Ammonium Chloride	HCID 25517	—
반응물	4,5,6,7-Tetrahydro-1-benzofuran-4-one	HCID 2733541	—
반응물	HCID 178418682	HCID 178418682	—
용매	Ethyl Acetate	HCID 8857	—
생성물	4-n-Butylidene-4,5,6,7-tetrahydrobenzo[b]furan	HCID 54518756	—

반응 단계

To a mixture of 4-oxo-4,5,6,7-tetrahydrobenzo[b]furan (20.06 g) and THF (200 ml) was added dropwise 2M n-butylmagnesium bromide with ice-water cooling over 15 minutes. The mixture was stirred at r.t. overnight. The reaction mixture was poured into a mixture of a saturated aqueous solution of NH4Cl and AcOEt. The separated organic layer was washed with water and brine, and dried over MgSO4, and evaporated. The resulting oil was purified by chromatography on SiO2 (CHCl3 as eluent) to give 4-n-butylidene-4,5,6,7-tetrahydrobenzo[b]furan as a yellow oil (12.06 g).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06093710
출처 데이터셋	uspto-grants-2000_07
ORD ID	ord-b734d03058194cb3b02b48b65a261790
출처 메모	uspto-grants-2000_07