4,6-Dichloro-2-ethylpyrimidine → 1-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

HRID 2289550노트

반응식

HRID 2289550 반응식
[CH3:1][C:2]1([C:8]([O:10]CC)=[O:9])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:13]([C:15]1[N:20]=[C:19](Cl)[CH:18]=[C:17](Cl)[N:16]=1)[CH3:14]>C(O)C.CCN(CC)CC>[CH2:13]([C:15]1[N:20]=[C:19]([N:5]2[CH2:4][CH2:3][C:2]([CH3:1])([C:8]([OH:10])=[O:9])[CH2:7][CH2:6]2)[CH:18]=[CH:17][N:16]=1)[CH3:14]

참가 물질

5

반응물 2

HCID 5184654,6-Dichloro-2-ethylpyrimidineHCID 19361805Ethyl 4-methylpiperidine-4-carboxylate

생성물 1

HCID 186980471-(2-Ethylpyrimidin-4-yl)-4-methyl-piperidine-4-carboxylic acid

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 8471Triethylamine용매

실험 절차

1-(2-Ethylpyrimidin-4yl)-4-methyl-piperidine-4-carboxylic acid was prepared on a 3 mmol 4-methyl-4-ethoxycarbonyl-piperidine (as TFA salt) in 7 ml ethanol and 1 ml Et3N treated with a solution of 0.531 g 2-ethyl-4,6-dichloropyrimidine in 4 ml ethanol. After 20 hours at ambient temp. The ethanol was removed and the residue partitioned between water and ethanol, washed with sodium hydrogen carbonate solution and brine. Evaporated to give gum (88.3%).

후처리

  1. customThe ethanol was removed
  2. customthe residue partitioned between water and ethanol
  3. washwashed with sodium hydrogen carbonate solution and brine
  4. customEvaporated

출처 및 근거

ORD 기록
ord-612357af215049ceae5b4f7b5693025e
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093718

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