4-Hydroxymethyl-1-(3-chlorophenyl)-1H-pyridin-2-one → 1-(3-Chloro-phenyl)-2-oxo-1,2-dihydro-pyridine-4-carbaldehyde
반응식
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=2)[C:5](=[O:16])[CH:4]=1>C(Cl)Cl.O=[Mn]=O>[Cl:15][C:11]1[CH:10]=[C:9]([N:6]2[CH:7]=[CH:8][C:3]([CH:2]=[O:1])=[CH:4][C:5]2=[O:16])[CH:14]=[CH:13][CH:12]=1참가 물질
4
실험 절차
To a solution of 4-hydroxymethyl-1-(3-chlorophenyl)-1H-pyridin-2-one (2.39 g, 10.14 mmol) in CH2Cl2 (250 ml) was added MnO2 (4.41 g, 50.71 mmol) and stirred for 18 hours. The suspension was filtered through celite and the pad washed with additional CH2Cl2 (200 ml). The combined filtrates were evaporated in vacuo and chromatographed (silica gel, 5-20% EtOAc: CH2Cl2 gradient elution) to afford the title compound.
후처리
- filtrationThe suspension was filtered through celite
- washthe pad washed with additional CH2Cl2 (200 ml)
- customThe combined filtrates were evaporated in vacuo
- customchromatographed
- wash(silica gel, 5-20% EtOAc: CH2Cl2 gradient elution)
출처 및 근거
- ORD 기록
- ord-8092fa023ba84a0997d2cb42ad3da008
- 출처 데이터셋
- uspto-grants-2000_07
- 특허 번호
- US06093737
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