Oxalyl chloride → 1,4-Dichloro-7-isoquinolinecarbonyl chloride

HRID 2289819노트

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HRID 2289819 반응식
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=C(C(O)=O)[CH:16]=2)[C:11]([Cl:21])=[CH:10][N:9]=1>C(Cl)Cl.CN(C=O)C>[Cl:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:1]([C:2]([Cl:4])=[O:3])[CH:16]=2)[C:11]([Cl:21])=[CH:10][N:9]=1

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 186982431,4-Dichloro-7-isoquinolinecarboxylic acid

생성물 1

HCID 186981881,4-Dichloro-7-isoquinolinecarbonyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

Anal. Found: C, 49.59; H, 2.08; N, 5.74. Calc for C10H5Cl2NO2 : C, 49.62; H, 2.08; N, 5.78. ##STR170## Oxalyl chloride (144 μL, 1.65 mmol) was added to a suspension of 1,4-dichloro-7-isoquinolinecarboxylic acid (200 mg, 0.83 mmol) at room temperature in CH2Cl2 (10 mL), followed by DMF (1 drop). After 30 min the resultant clear solution was evaporated in vacuo to afford 1,4-dichloro-7-isoquinolinecarbonyl chloride which was used without further purification.

후처리

  1. customAfter 30 min the resultant clear solution was evaporated in vacuo

출처 및 근거

ORD 기록
ord-e008b04eccea4bfc9ff503e33b0eebc9
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093731

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