Pivaloyl chloride → HCID 178447243, 화합물

HRID 2289839노트

반응식

HRID 2289839 반응식
[NH2:1][C:2]1[NH:7][C:6]2=[N:8][CH:9]=[CH:10][C:5]2=[C:4]([Cl:11])[N:3]=1.[C:12](Cl)(=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14]>N1C=CC=CC=1>[C:12]([NH:1][C:2]1[NH:7][C:6]2=[N:8][CH:9]=[CH:10][C:5]2=[C:4]([Cl:11])[N:3]=1)(=[O:17])[C:13]([CH3:16])([CH3:15])[CH3:14]

참가 물질

4

반응물 2

HCID 62493Pivaloyl chlorideHCID 178508434HCID 178508434, 화합물

생성물 1

HCID 178447243HCID 178447243, 화합물수율 83%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 2-amino-4-chloro-pyrrolo[2,3-d]pyrimidine (20 g, 118 mmol) and pivaloyl chloride (14.3 g, 118 mmol) in pyridine (150 mL) was stirred for 18 hours at ambient temperature. The resulting dark red solution was evaporated to an amber solid which was co-evaporated with water (20 mL, 3×). The resulting solid was filtered, washed with cold water and then dried over KOH in vacuo to yield 22 g (83%) of 2-pivaloylamino-4-chloro-pyrrolo[2,3-d]pyrimidine as a reddish solid. 1H-NMR (DMSO-d6): δ 12.35 (bs, 1, N (7)-H); 10.07 (s,1, N (2)-H); 7.56 (m,1, H-6); 6.58 (m,1, H-5); 1.24 (s, 9, pivaloyl methyls). mp>210° C.

후처리

  1. customThe resulting dark red solution was evaporated to an amber solid which
  2. filtrationThe resulting solid was filtered
  3. washwashed with cold water
  4. dry with materialdried over KOH in vacuo

출처 및 근거

ORD 기록
ord-e0f8d61a8926405c9d4cd60ba4e781a0
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093807

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