p-Toluenesulfonic acid → HCID 178522900, 화합물

HRID 2289957노트

반응식

HRID 2289957 반응식
[NH2:1][C:2](=[S:26])[C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([F:13])[CH:12]=1)[N:9]=[CH:8][C:7]([C:14]([NH:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)=[O:15])=[C:6]2[OH:25].[C:27]1(C)C=CC(S(O)(=O)=O)=C[CH:28]=1.C(OC(OCC)CBr)C>C(O)(=O)C.C(OCC)(=O)C>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][NH:16][C:14]([C:7]2[CH:8]=[N:9][C:10]3[C:5]([C:6]=2[OH:25])=[CH:4][C:3]([C:2]2[S:26][CH:27]=[CH:28][N:1]=2)=[CH:12][C:11]=3[F:13])=[O:15])=[CH:19][CH:20]=1

참가 물질

6

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 74852Ethane, 2-bromo-1,1-diethoxy-HCID 178514136HCID 178514136, 화합물

생성물 1

HCID 178522900HCID 178522900, 화합물수율 544.9%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 8857Ethyl Acetate용매

반응 조건

온도
100 °C

실험 절차

To a suspension of the title compound of Example 52 (0.14 g) and p-toluenesulfonic acid (0.0084 g) in 2 mL acetic acid is added bromoacetaldehyde diethyl acetal (0.08 mL). The reaction is heated at 100° C. for approximately 45 minutes. The reaction is cooled to room temperature and diluted with 30 mL ethyl acetate. The solid is filtered and dried to give the desired product (0.11 g).

후처리

  1. temperatureThe reaction is cooled to room temperature
  2. filtrationThe solid is filtered
  3. customdried

출처 및 근거

ORD 기록
ord-709e3ffad828433a92aa5f1ac4cc2745
출처 데이터셋
uspto-grants-2000_07
특허 번호
US06093732

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