Sodium Iodide → 1-Iodo-2-methylpropyl 3-methylbutyrate

HRID 2290200노트

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HRID 2290200 반응식
[I-:1].[Na+].[CH3:3][CH:4]([CH3:14])[CH2:5][C:6]([O:8][CH:9](Cl)[CH:10]([CH3:12])[CH3:11])=[O:7]>C(#N)C>[CH3:3][CH:4]([CH3:14])[CH2:5][C:6]([O:8][CH:9]([I:1])[CH:10]([CH3:12])[CH3:11])=[O:7]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 136045391-Chloro-2-methylpropyl 3-methylbutyrate

생성물 1

HCID 140301271-Iodo-2-methylpropyl 3-methylbutyrate수율 56.5%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Acetonitrile (200 ml) is warmed to 60° C. and in this solvent is dissolved 35 g of sodium iodide. To this solution is added 12 g of 1-chloro-2-methylpropyl 3-methylbutyrate as obtained by the above procedure (a), and the mixture is stirred for 40 minutes, poured into 500 ml of ice water and extracted with hexane. The extract is washed with water and then with 5% aqueous sodium thiosulfate and dried over anhydrous magnesium sulfate. The solvent is then distilled off under reduced pressure to give 10 g of 1-iodo-2-methylpropyl 3-methylbutyrate.

후처리

  1. customas obtained by the above procedure (a)
  2. extractionextracted with hexane
  3. washThe extract is washed with water
  4. dry with materialwith 5% aqueous sodium thiosulfate and dried over anhydrous magnesium sulfate
  5. distillationThe solvent is then distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-0e54df3271074ce0b8cf95ef37faf2df
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616008

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