Ethanol → HCID 20231999, 화합물

HRID 2290225노트

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[CH2:1]([C:3](=[CH:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-])=O)[CH:9]=1)[C:4]([OH:6])=[O:5])[CH3:2].[CH2:17]([OH:19])[CH3:18]>>[C:17]([NH:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[CH2:7][CH:3]([CH2:1][CH3:2])[C:4]([OH:6])=[O:5])(=[O:19])[CH3:18]

참가 물질

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HCID 702Ethanol

HCID 990102-Ethyl-3-(3-nitrophenyl)propenoic acid

생성물 1

HCID 20231999HCID 20231999, 화합물

실험 절차

In a manner similar to Description 13, 2-ethyl-3-(3-nitrophenyl)propenoic acid was reduced and acetylated to give 2-(3-acetamidobenzyl)butanoic acid, m.p. 131°-132° C. (from aqueous ethanol) which was cyclised and the product hydrolysed to afford 5-amino-2-ethylindan-1-one, m.p. 105.5°-108° C. (from acetonitrile). Acetylation of the latter afforded 5-acetamido-2-ethylindan-1-one, m.p. 154°-155° C. (from acetonitrile).

출처 및 근거

ORD 기록: ord-b33db33c81404b60b30e64bd18c15f92
출처 데이터셋: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04616013

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