Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2290239생성일: 2026년 10월 24일
1-(3-Fluoro-2-pyridinyl)piperazine → 1-[3-(2-Cyanophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl)piperazine
https://huagongshe.com/ko/reaction/2290239
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-(3-Fluoro-2-pyridinyl)piperazine | HCID 134987 | — |
| 반응물 | 2-(Oxiran-2-ylmethoxy)benzonitrile | HCID 12619671 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 1-[3-(2-Cyanophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl)piperazine | HCID 20232176 | 74.1% |
반응 단계
To a solution of 1-(3-fluoro-2-pyridyl)piperazine (453 mg, 2.5 mmol) in 5 ml of isopropanol stirred at 70° C. under nitrogen was added portionwise 2-cyanophenoxy-2,3-epoxypropane (438 mg, 2.5 mmol) and the mixture stirred for 21/2 hours at 70° C. The solvent was removed in vacuo at room temperature and the residual oil was chromatographed on silica gel eluting with 5% methanol-chloroform. The product was obtained as a colorless oil which slowly solidified upon trituration in hexane to yield 0.66 g of 1-[3-(2-cyanophenoxy)-2-hydroxypropyl]-4-(3-fluoro-2-pyridyl)piperazine; m.p. 68°-70° C. Analysis satisfactory for C19H21FN4O2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US04616017 |
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| 출처 데이터셋 | uspto-grants-1986_10 |
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| ORD ID | ord-8f171575cdc84df4a117f7a9212a0927 |
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| 출처 메모 | uspto-grants-1986_10 |
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