Methanethiol → {3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide

HRID 2290260노트

반응식

HRID 2290260 반응식
CS(=[N:7][C:8]#[N:9])C(=S)OC.[CH3:10][O:11][C:12]1[CH:22]=[CH:21][C:15]([CH2:16][NH:17][CH2:18][CH2:19][SH:20])=[CH:14][CH:13]=1.[CH3:23]S>C(O)C>[C:8]([N:7]=[C:23]1[N:17]([CH2:16][C:15]2[CH:21]=[CH:22][C:12]([O:11][CH3:10])=[CH:13][CH:14]=2)[CH2:18][CH2:19][S:20]1)#[N:9]

참가 물질

5

반응물 3

HCID 878MethanethiolHCID 14306201N-(4-methoxybenzyl)-cysteamineHCID 87522899Cyanimino-dithiocarbonic acid dimethylester

생성물 1

HCID 14306204{3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3.65 g (23.5 moles) of cyanimino-dithiocarbonic acid dimethylester (purity: 94%) and 5.91 (30 moles) of N-(4-methoxybenzyl)-cysteamine are boiled in 30 ml of ethanol until the evolution of methyl mercaptan terminates. The reaction mixture is evaporated and the crystalline residue is recrystallized from 15 ml of isopropanol. 5.35 g (92%) of 2-cyanimino-3-(4-methoxybenzyl)-thiazolidine are obtained, melting at 99° to 102° C.

후처리

  1. customThe reaction mixture is evaporated
  2. customthe crystalline residue is recrystallized from 15 ml of isopropanol

출처 및 근거

ORD 기록
ord-da11e47810b3438c9a5b4916232a9061
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616025

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