Ammonium Hydroxide → 2-Cyanimino-3-(4-hydroxy-benzyl)-thiazolidine

HRID 2290262노트

반응식

HRID 2290262 반응식
[C:1]([N:3]=[C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16]C)=[CH:12][CH:11]=2)[CH2:7][CH2:6][S:5]1)#[N:2].[OH-].[NH4+]>ClCCl>[C:1]([N:3]=[C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[CH2:7][CH2:6][S:5]1)#[N:2]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 14306204{3-[(4-Methoxyphenyl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide

생성물 1

HCID 143062082-Cyanimino-3-(4-hydroxy-benzyl)-thiazolidine수율 0%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

0.49 g (2 moles) of 2-cyanimino-3-(4-methoxybenzyl)-thiazolidine are dissolved in 12 ml of dichloromethane and a solution of 3.01 g (1.14 ml, 13 mmoles) of borotribromide in 5 ml of dichloromethane is added in an argon atmosphere, dropwise. The mixture is stirred for 12 hours and is then alkalized with an aqueous ammonium hydroxide solution, under stirring and cooling. The phases are separated and the organic phase is evaporated. 0.22 g of 2-cyanimino-3-(4-hydroxy-benzyl)-thiazolidine are obtained in a white crystalline form, melting at 175° to 177° C.

후처리

  1. stirringunder stirring
  2. temperaturecooling
  3. customThe phases are separated
  4. customthe organic phase is evaporated

출처 및 근거

ORD 기록
ord-381a7baed05e437f92d1bca03ee64567
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616025

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