Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine Dihydrochloride → Methyl 4-[(piperazin-1-yl)methyl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine Dihydrochloride | HCID 8893 | — |
| 반응물 | Piperazine, hexahydrate | HCID 120181 | — |
| 반응물 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 4-[(piperazin-1-yl)methyl]benzoate | HCID 7018627 | 64% |
반응 단계
A mixtue of 38 g. (0.2 mole) piperazine hexahydrate, 28 g. (0.2 mole) piperazine dihydrochloride and 150 ml. methanol is mixed, while stirring at ambient temperature, with 45 g. (0.2 mole) methyl 4-bromomethylbenzoate. The reaction mixture is left to stand for 2 days and suction filtered from the precipitate. The clear solution is evaporated and the residue is recrystallised from ethanol to give 39 g. (64%) of the desired compound as a monohydrochloride; m.p. 226°-227° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04616086 |
| 출처 데이터셋 | uspto-grants-1986_10 |
| ORD ID | ord-c2a1209efed14541a56982e6500c44bc |
| 출처 메모 | uspto-grants-1986_10 |