Piperazine Dihydrochloride → Methyl 4-[(piperazin-1-yl)methyl]benzoate

HRID 2290450

반응식

HRID 2290450 반응식
O.O.O.O.O.O.[NH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.Cl.Cl.N1CCNCC1.Br[CH2:22][C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=1>CO>[N:7]1([CH2:22][C:23]2[CH:32]=[CH:31][C:26]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][CH:24]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1

참가 물질

5

반응물 3

HCID 8893Piperazine DihydrochlorideHCID 120181Piperazine, hexahydrateHCID 256687Methyl 4-(bromomethyl)benzoate

생성물 1

HCID 7018627Methyl 4-[(piperazin-1-yl)methyl]benzoate수율 64%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixtue of 38 g. (0.2 mole) piperazine hexahydrate, 28 g. (0.2 mole) piperazine dihydrochloride and 150 ml. methanol is mixed, while stirring at ambient temperature, with 45 g. (0.2 mole) methyl 4-bromomethylbenzoate. The reaction mixture is left to stand for 2 days and suction filtered from the precipitate. The clear solution is evaporated and the residue is recrystallised from ethanol to give 39 g. (64%) of the desired compound as a monohydrochloride; m.p. 226°-227° C.

후처리

  1. waitThe reaction mixture is left
  2. filtrationsuction filtered from the precipitate
  3. customThe clear solution is evaporated
  4. customthe residue is recrystallised from ethanol
  5. customto give 39 g

출처 및 근거

ORD 기록
ord-c2a1209efed14541a56982e6500c44bc
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616086

연결된 노트

불러오는 중…