Propylene Oxide → Methyl 4-[1-(2-hydroxypropyl)-piperazin-4-ylmethyl]-benzoate

HRID 2290452

반응식

HRID 2290452 반응식
[N:1]1([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH2:18]1[O:21][CH:19]1[CH3:20]>>[OH:21][CH:19]([CH3:20])[CH2:18][N:4]1[CH2:5][CH2:6][N:1]([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:2][CH2:3]1

참가 물질

3

반응물 2

HCID 6378Propylene OxideHCID 7018627Methyl 4-[(piperazin-1-yl)methyl]benzoate

생성물 1

HCID 54404285Methyl 4-[1-(2-hydroxypropyl)-piperazin-4-ylmethyl]-benzoate수율 63%

실험 절차

This is prepared analogously to Example 11 from methyl 4-(piperazin-1-ylmethyl)-benzoate and propylene oxide. Yield 63% of theory; m.p. 63°-64° C.

출처 및 근거

ORD 기록
ord-104689d171e04e2fb64f2830cf80e88e
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616086

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