4-Chlorobenzoyl chloride → Methyl 4-[1-(4-chlorobenzoyl)-piperazin-4-ylmethyl]-benzoate

HRID 2290453

반응식

HRID 2290453 반응식
[N:1]1([CH2:7][C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>N1C=CC=CC=1>[Cl:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([N:4]2[CH2:5][CH2:6][N:1]([CH2:7][C:8]3[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=3)[CH2:2][CH2:3]2)=[O:24])=[CH:21][CH:20]=1

참가 물질

4

반응물 2

HCID 85014-Chlorobenzoyl chlorideHCID 7018627Methyl 4-[(piperazin-1-yl)methyl]benzoate

생성물 1

HCID 54279459Methyl 4-[1-(4-chlorobenzoyl)-piperazin-4-ylmethyl]-benzoate

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 15.3 g. (50 mmole) methyl 4-(piperazin-1-ylmethyl)-benzoate and 175 ml. anhydrous pyridine, there is added dropwise, at 0°-5° C., 8.7 g. (50 mmole) 4-chlorobenzoyl chloride and the reaction mixture kept for a further hour at 0° to 5° C., then overnight at 20° C. The reaction mixture is stirred into ice water and the precipitated product is filtered off with suction, washed with water and dried to give 18.5 g. (quantitative) of the desired product; m.p. 134°-135° C.

후처리

  1. customovernight
  2. customat 20° C
  3. filtrationthe precipitated product is filtered off with suction
  4. washwashed with water
  5. customdried
  6. customto give 18.5 g

출처 및 근거

ORD 기록
ord-6dc8888c09b34dc5bb0d689ff177e249
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04616086

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