1-(4-Chlorophenyl)piperazine → HCID 20232521, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Br[CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH2:13][CH2:12][N:11]([CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][C:20]([C:23](=[O:25])[CH3:24])=[CH:19][CH:18]=3)[CH2:10][CH2:9]2)=[CH:6][CH:7]=1

참가 물질

반응물 2

HCID 974781-(4-Chlorophenyl)piperazine

HCID 6111941-(4-(2-Bromoethyl)phenyl)ethan-1-one

생성물 1

HCID 20232521HCID 20232521, 화합물수율 64%

실험 절차

By the reaction of 1-(4-chlorophenyl)-piperazine with 4'-(2-bromoethyl)-acetophenone analogously to Example (41a), there is obtained 4'-{2-[1-(4-chlorophenyl)-piperazin-4-yl]-ethyl}-acetophenone. Yield 64% of theory; m.p. 141°-143° C. (recrystallised from ethyl acetate).

출처 및 근거

ORD 기록: ord-0cd9bd76e1fb4cee992783f314e98614
출처 데이터셋: uspto-grants-1986_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04616086

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