Potassium Carbonate → Piritetrate

HRID 2290608

반응식

HRID 2290608 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH:9][CH3:10])[N:4]=1.C(=O)([O-])[O-].[K+].[K+].Cl[C:18]([O:20][C:21]1[CH:30]=[CH:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=1)=[S:19]>CC(C)=O>[CH3:1][O:2][C:3]1[N:4]=[C:5]([N:9]([CH3:10])[C:18](=[S:19])[O:20][C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=2)[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 82681O-2-Naphthyl chlorothioformateHCID 70191686-methoxy-N-methylpyridin-2-amine

생성물 1

HCID 145908Piritetrate수율 84.9%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

To the mixture of 1.38 g of 2-methoxy-6-methylaminopyridine, which is one of the compounds of this invention, and the same amount of anhydrous potassium carbonate in 20 ml of acetone, 2.23 g of O-2-naphthyl chlorothioformate dissolved in 20 ml of acetone was added under stirring at room temperature. After 30 minutes, the reaction mixture was extracted with benzene, washed with water, dried and recrystallized to give 2.75 g of O-2-naphthyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate.

후처리

  1. additionwas added
  2. extractionthe reaction mixture was extracted with benzene
  3. washwashed with water
  4. customdried
  5. customrecrystallized

출처 및 근거

ORD 기록
ord-e353faaeb4a345408ac3d62c39eb4382
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04617397

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