Sulfuric Acid → HCID 178433476, 화합물
반응식
S(=O)(=O)(O)[OH:2].[CH3:6][C:7]1[N:12]=[C:11](Cl)[C:10]([F:14])=[C:9]([Cl:15])[N:8]=1.[Cl-].[Na+]>O>[CH3:6][C:7]1[N:12]=[C:11]([OH:2])[C:10]([F:14])=[C:9]([Cl:15])[N:8]=1참가 물질
5
실험 절차
To a mixture of water (3 mL) and concentrated sulfuric acid (7 mL) was added 1.81 g (10 mmol) of 2-methyl-4,6-dichloro-5-fluoropyrimidine. The reaction mixture was stirred for 3 hours and then poured onto ice. The mixture was saturated with sodium chloride and extracted with ethyl acetate. The organic extracts were combined, dried (MgSO4), filtered, and concentrated in vacuo to give crude product (1.4 g, 86%), m.p. 214°-216° C. This product was used in subsequent reactions without further purification.
후처리
- additionpoured onto ice
- extractionextracted with ethyl acetate
- dry with materialdried (MgSO4)
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-e674853e7e3c4ca8812fe602d86d5049
- 출처 데이터셋
- uspto-grants-1986_10
- 특허 번호
- US04617393
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