Ammonia → HCID 20230261, 화합물

HRID 2290783노트

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HRID 2290783 반응식
Cl[CH2:2][C:3]1[N:7]=[C:6]([CH:8]([CH3:22])[C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:11]([F:21])[CH:10]=2)[O:5][N:4]=1.[NH3:23]>>[NH2:23][CH2:2][C:3]1[N:7]=[C:6]([CH:8]([CH3:22])[C:9]2[CH:14]=[CH:13][C:12]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[C:11]([F:21])[CH:10]=2)[O:5][N:4]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 136909413-Chloromethyl-5-(3-fluoro-4-phenyl-alpha-methylbenzyl)-1,2,4-oxadiazole

생성물 1

HCID 20230261HCID 20230261, 화합물

실험 절차

A mixture of 6.0 g of 3-chloromethyl-5-(3-fluoro-4-phenyl-α-methylbenzyl)-1,2,4-oxadiazole and 50 ml of liquid ammonia was allowed to stand in an autoclave at room temperature overnight. After evaporation of ammonia, the residue was chromatographed over silica gel using chloroform to give 4.05 g of 3-aminomethyl-5-(3-fluoro-4-phenyl-α-methylbenzyl)-1,2,4-oxadiazole as a light brown oil, nD22 1.5878.

후처리

  1. customAfter evaporation of ammonia
  2. customthe residue was chromatographed over silica gel

출처 및 근거

ORD 기록
ord-8d6150d967384b67a010ae502266825f
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04618617

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