Thionyl Chloride → 10-Benzyloxy-1-chlorodecane

HRID 2290807

반응식

HRID 2290807 반응식
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18]O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>CN(C)C=O>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][Cl:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 110108641-Decanol, 10-(phenylmethoxy)-

생성물 1

HCID 1106593210-Benzyloxy-1-chlorodecane

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 7 g of 10-benzyloxy-1-decanol, 8 ml of thionyl chloride, and 0.2 ml of dimethylformamide was heated to 50° to 60° C. for one hour. After the reaction was over, the reaction mixture was concentrated under reduced pressure, the residue was dissolved in 50 ml of n-hexane, and after washing the solution with water, the solution was dried over anhydrous magnesium sulfate. Then, the solvent was distilled off and the residue was applied to silica gel column chromatography and eluted with toluene to provide 6.7 g of oily 10-benzyloxy-1-chlorodecane. Boiling point 135°-140° C. (0.6-0.9 mm Hg).

후처리

  1. temperaturewas heated to 50° to 60° C. for one hour
  2. concentrationwas concentrated under reduced pressure
  3. dissolutionthe residue was dissolved in 50 ml of n-hexane
  4. washafter washing the solution with water
  5. dry with materialthe solution was dried over anhydrous magnesium sulfate
  6. distillationThen, the solvent was distilled off
  7. washeluted with toluene

출처 및 근거

ORD 기록
ord-c368d9fdd8dc4700bb4ebdb9d900c8f9
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04618627

연결된 노트

불러오는 중…