Trichloroacetic Acid → 97139-59-8

HRID 2290841노트

반응식

HRID 2290841 반응식
[CH2:1]([NH:8][C:9](=[O:12])[NH:10][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC(Cl)(Cl)C(O)=O.[CH2:20]1[CH:26](O)[NH:25][P:23]([N:28]([CH2:32][CH2:33][Cl:34])[CH2:29][CH2:30][Cl:31])(=[O:24])[O:22][CH2:21]1>CC(C)=O.C(Cl)Cl>[CH2:1]([NH:8][C:9](=[O:12])[N:10]([OH:11])[CH:26]1[CH2:20][CH2:21][O:22][P:23]([N:28]([CH2:32][CH2:33][Cl:34])[CH2:29][CH2:30][Cl:31])(=[O:24])[NH:25]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 6421Trichloroacetic AcidHCID 997354-HydroxycyclophosphamideHCID 13770898N-Benzyl-N'-hydroxyurea

생성물 1

HCID 1377089997139-59-8

시약·촉매·용매 2

HCID 180Acetone용매HCID 6344Dichloromethane용매

실험 절차

540 mg (3.25 mmol) of 3-benzyl-1-hydroxyurea in 40 ml of acetone and a catalytic amount of trichloroacetic acid were added to 900 mg (3.25 mmol) of 4-hydroxycyclophosphamide in 1 ml of methylenechloride. The mixture was stored overnight at -25° C., the crystals were then drawn off by suction, washed with acetone and ether and recrystallized from ethyl acetate.

후처리

  1. washwashed with acetone and ether
  2. customrecrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-98245b4734e949f4abb48ec7ade04ca1
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04618692

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