2-(2-Methoxyphenoxy)acetic acid → 2,3,3a,4,5,9b-Hexahydro-6-methoxy-2-(2-methoxyphenoxy)acetyl-1H-benz[e]isoindole

HRID 2290914

반응식

HRID 2290914 반응식
Cl.[CH3:2][O:3][C:4]1[C:16]2[CH2:15][CH2:14][CH:13]3[CH:9]([CH2:10][NH:11][CH2:12]3)[C:8]=2[CH:7]=[CH:6][CH:5]=1.[CH3:17][O:18][C:19]1[CH:29]=[CH:28][CH:27]=[CH:26][C:20]=1[O:21][CH2:22][C:23](O)=[O:24]>>[CH3:2][O:3][C:4]1[C:16]2[CH2:15][CH2:14][CH:13]3[CH:9]([CH:10]([C:23](=[O:24])[CH2:22][O:21][C:20]4[CH:26]=[CH:27][CH:28]=[CH:29][C:19]=4[O:18][CH3:17])[NH:11][CH2:12]3)[C:8]=2[CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 158822-(2-Methoxyphenoxy)acetic acidHCID 190648382,3,3a,4,5,9b-Hexahydro-6-methoxy-1H-benz[e]isoindole hydrochloride

생성물 1

HCID 704539062,3,3a,4,5,9b-Hexahydro-6-methoxy-2-(2-methoxyphenoxy)acetyl-1H-benz[e]isoindole수율 86%

실험 절차

Using the procedure described in example 14, but starting with the product of example 27 and o-methoxyphenoxyacetic acid afforded the desired compound, (86%).

출처 및 근거

ORD 기록
ord-2b895e34f431469f83ad4ae5ffb0d223
출처 데이터셋
uspto-grants-1986_10
특허 번호
US04618683

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