Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methylhomoveratrylamine → 3,4-Dichloro-N-[4-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]butyl]-N-(1-methylethyl)benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methylhomoveratrylamine | HCID 77039 | — |
| 반응물 | N-isopropyl-N-(4-oxobutyl)-3,4-dichlorobenzenesulfonamide | HCID 13770967 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3,4-Dichloro-N-[4-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]butyl]-N-(1-methylethyl)benzenesulfonamide | HCID 13770968 | — |
반응 단계
The aldehyde prepared in the preceding paragraph (8.90 g, 0.027 m) and N-methyl-homoveratrylamine (5.29 g, 0.027 m) in absolute ethanol (100 ml) containing PtO2 (0.6 g) was shaken under hydrogen (7 hours) and the reaction filtered and stripped to provide the crude product (13.32 g) as a dark greenish gum. This material was chromatographed, after removal of a small amount of insoluble solid, on dry column silica gel (500 g) with 30% methanol/70% ethyl acetate to provide the title compound (7.26 g) as a clear white gum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04618711 |
| 출처 데이터셋 | uspto-grants-1986_10 |
| ORD ID | ord-fe203a9032f446659f56f459b8ba90a1 |
| 출처 메모 | uspto-grants-1986_10 |