Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Acetate → (r)-2-(3-{3-[[2-Fluoro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)acetic acid hydrochloride salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Acetate | HCID 6584 | — |
| 반응물 | 2-Fluoro-3-(trifluoromethyl)benzaldehyde | HCID 517978 | — |
| 반응물 | 2-Chloro-3-(trifluoromethyl)benzaldehyde | HCID 2736672 | — |
| 반응물 | Ether hydrochloride | HCID 10953452 | — |
| 반응물 | (R)-2-(3-{3-[(2,2-diphenylethyl)amino]2-methyl-propoxy}phenyl)acetic acid | HCID 68862792 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | (r)-2-(3-{3-[[2-Fluoro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-2-methyl-propoxy}-phenyl)acetic acid hydrochloride salt | HCID 68862741 | — |
반응 단계
Following the procedure of Example 7(d) except (R)-2-(3-{3-[(2,2-diphenylethyl)amino]2-methyl-propoxy}phenyl)acetic acid and 2-fluoro-3-trifluoromethylbenzaldehyde were used instead of (R)-2-(3-{3-(2,2-diphenylethyl)amino]-3-methyl-propoxy}-phenyl)acetic acid methyl ester and 2-chloro-3-trifluoromethylbenzaldehyde in step (d) the corresponding carboxylic acid was obtained. The resulting amine/carboxylic acid was dissolved in Et2O (diethylether) and acidified with 1.0 M HCl/Et2O. The reaction mixture was concentrated in vacuo and dried under reduced pressure to give the title compound as a white solid, 73 mg (68%). MS (ESI) 580.4 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07560586B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-8097fe1fafd243a29f684da5682b24b7 |
| 출처 메모 | uspto-grants-2009_07 |