Ammonia → HCID 4914114, 화합물

HRID 2291284노트

반응식

HRID 2291284 반응식
[CH:1]1([N:4]2[C:13]3[C:8](=[C:9](F)[C:10]([F:22])=[C:11]([N:15]4[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]4)[C:12]=3[F:14])[C:7](=[O:24])[C:6]([C:25]([OH:27])=[O:26])=[CH:5]2)[CH2:3][CH2:2]1.[NH3:28]>CN(C)C=O>[NH2:28][C:9]1[C:10]([F:22])=[C:11]([N:15]2[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH2:20]2)[C:12]([F:14])=[C:13]2[C:8]=1[C:7](=[O:24])[C:6]([C:25]([OH:27])=[O:26])=[CH:5][N:4]2[CH:1]1[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 13825520HCID 13825520, 화합물

생성물 1

HCID 4914114HCID 4914114, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In the same manner as described in Example 13, 1-cyclopropyl-5,6,8-trifluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid was allowed to react with ammonia in dimethylformamide in a sealed tube to give 5-amino-1-cyclopropyl-6,8-difluoro-7-(4-methyl-1-piperazinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, m.p. 254°-255° C.

출처 및 근거

ORD 기록
ord-77fb75cf9ba24361bc32b863c15d3f13
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04795751

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