Ammonia → 4-[2-(2-[2,2,2-Trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile

HRID 2291321노트

반응식

HRID 2291321 반응식
[F:1][C:2]([F:21])([F:20])[CH2:3][NH:4][C:5](=S)[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1.[NH3:22]>CCO>[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([S:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 537498974-[2-(3-[2,2,2-Trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile

생성물 1

HCID 212797494-[2-(2-[2,2,2-Trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 4-[2-(3-[2,2,2-trifluoroethyl]thioureido)pyrid-6-ylthio]butyronitrile (29 g.), yellow mercuric oxide (29 g.) and a saturated solution of ammonia in EtOH (100 ml.) was stirred at room temperature for 24 hours and then filtered. The filtrate was evaporated to dryness and the residue triturated with petroleum ether (b.p. 60°-80°) and collected to give 4-[2-(2-[2,2,2-trifluoroethyl]guanidino)pyrid-6-ylthio]butyronitrile (24 g.), m.p. 89°-91°.

후처리

  1. filtrationfiltered
  2. customThe filtrate was evaporated to dryness
  3. customthe residue triturated with petroleum ether (b.p. 60°-80°)
  4. customcollected

출처 및 근거

ORD 기록
ord-d116a4c989cc4fb8b8e39baf6176460c
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04795755

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