Diethyl Ether → 5-(4-[2-(2,2,2-Trifluoroethyl)guanidino]pyrimid-2-yloxy)valeramidine hydrochloride

HRID 2291326노트

반응식

HRID 2291326 반응식
[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18](=[NH:21])OC)[N:8]=1.[Cl-:25].[NH4+:26].CCOCC>CO>[ClH:25].[F:1][C:2]([F:24])([F:23])[CH2:3][N:4]=[C:5]([NH2:22])[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([NH2:26])=[NH:21])[N:8]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 25517Ammonium ChlorideHCID 21279807Methyl 5-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-yloxy)valerimidate

생성물 1

HCID 212797305-(4-[2-(2,2,2-Trifluoroethyl)guanidino]pyrimid-2-yloxy)valeramidine hydrochloride수율 95.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl 5-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-yloxy)valerimidate (1.5 g.) in MeOH (15 ml.) was treated with ammonium chloride (0.25 g.) and the solution stirred at room temperature for 2 hours. Ether was added until the solution became cloudy. Continued stirring caused precipitation of a solid which was filtered to give 5-(4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimid-2-yloxy)valeramidine hydrochloride, (1.52 g.), m.p. 156°-158°.

후처리

  1. stirringContinued stirring
  2. customprecipitation of a solid which
  3. filtrationwas filtered

출처 및 근거

ORD 기록
ord-d516a44a5aca40deb1aba7d8773b3ef1
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04795755

반응 노트

불러오는 중…