Aniline → N,N-Di(6-hydroxyhexyl)aniline

HRID 2291429

반응식

HRID 2291429 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8](=[O:11])([O-])[O-].[K+].[K+].Cl[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21]>>[OH:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][N:1]([CH2:4][CH2:3][CH2:2][CH2:7][CH2:6][CH2:8][OH:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 6115AnilineHCID 11430Potassium CarbonateHCID 748286-Chloro-1-hexanol

생성물 1

HCID 21982671N,N-Di(6-hydroxyhexyl)aniline수율 127%

실험 절차

A mixture of freshly distilled aniline (93 g, 1.10 mol), potassium carbonate (304 g, 2.2 mol), 6-chloro-1-hexanol (300.0 g, 2.2 mol), and 500 mL of η-butanol was heated at reflux for 82 hours under nitrogen with vigorous stirring. After cooling and filtering, the butanol was evaporated at reduced pressure to leave a tan oil. The oil was fractionally distilled in vacuo, yielding 205 g (70%) of A1 as a colorless oil, bp 195°-225° C. (0.15 nm).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 82 hours under nitrogen with vigorous stirring
  3. temperatureAfter cooling
  4. filtrationfiltering
  5. customthe butanol was evaporated at reduced pressure
  6. customto leave a tan oil
  7. distillationThe oil was fractionally distilled in vacuo

출처 및 근거

ORD 기록
ord-405f877d462048c0833a911c51b535a3
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04796971

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