4-Methanesulphonamidophenethyl mesylate → HCID 21278924, 화합물

HRID 2291569노트

반응식

HRID 2291569 반응식
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([NH:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:10][CH:9]=1)(=O)=O.[CH3:19][S:20]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)=[CH:26][C:25]=1[CH3:36])(=[O:22])=[O:21]>C(O)C>[CH3:19][S:20]([NH:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]2[CH2:35][CH2:34][N:33]([CH2:6][CH2:7][C:8]3[CH:9]=[CH:10][C:11]([NH:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:12][CH:13]=3)[CH2:32][CH2:31]2)=[CH:26][C:25]=1[CH3:36])(=[O:21])=[O:22]

참가 물질

4

반응물 2

HCID 149859624-Methanesulphonamidophenethyl mesylateHCID 54529973HCID 54529973, 화합물

생성물 1

HCID 21278924HCID 21278924, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Methanesulphonamidophenethyl methanesulphonate (1.47 g) and 1-(4-methanesulphonamido-3-methylphenyl)piperazine 1/4 hydrate (1.37 g) in ethanol (15 ml) were refluxed overnight, evaporated to dryness, and partitioned between ethyl acetate and water. The title compound (0.2 g) was filtered from the 2-phase mixture and recrystallised from methanol/acetone, yield 0.128 g, m.p. 235°-7°.

후처리

  1. customevaporated to dryness
  2. custompartitioned between ethyl acetate and water
  3. filtrationThe title compound (0.2 g) was filtered from the 2-phase mixture
  4. customrecrystallised from methanol/acetone, yield 0.128 g, m.p. 235°-7°

출처 및 근거

ORD 기록
ord-6e52fb03d0be4542964729bf1f2d6de9
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04797401

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