Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → HCID 131715814, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | (2S)-2-amino-5-(((tert-butoxy)carbonyl)amino)pentanoic acid | HCID 6993436 | — |
| 반응물 | Diethylether ethylacetate | HCID 21584169 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 131715814 | HCID 131715814 | 88% |
반응 단계
9.3 g of H-Orn(Boc)-OH, 5.0 g of the N-hydroxysuccinimide ester of acetic acid and 4.1 ml of NEM in 50 ml of DMF and 10 ml of H2O are allowed to react at room temperature for 3 days. The solvent is evaporated off in vacuo, and the residue is chromatographed on silica gel (system 4). 9.6 g of Ac-Orn(Boc)-OH (yield: 88%) readily crystallize from EA/diethyl ether. MS (FAB): 275 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04797471 |
| 출처 데이터셋 | uspto-grants-1989_01 |
| ORD ID | ord-cc0225c8c0df4c3c8555c5cce744e32b |
| 출처 메모 | uspto-grants-1989_01 |