Aniline → Diethyl 2-(phenylamino)fumarate

HRID 2291799노트

반응식

HRID 2291799 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]([O:18][CH2:19][CH3:20])(=[O:17])[CH2:9][C:10]([C:12]([O:14][CH2:15][CH3:16])=[O:13])=O>C1(C)C=CC=CC=1>[C:2]1([NH:1][C:9]([C:8]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 6115AnilineHCID 66951Diethyl oxalacetate

생성물 1

HCID 588882Diethyl 2-(phenylamino)fumarate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Aniline (0.217 mol) and diethyl oxalacetate (0.217 mol) are mixed in toluene (500 m) and heated to reflux, i.e., about 100° C., under a water separator for approximately one hour. The toluene is then removed under vacuum to afford the desired product, i.e., diethyl 3-phenylaminobut-2-ene-dioate.

후처리

  1. temperatureheated
  2. temperatureto reflux
  3. customThe toluene is then removed under vacuum

출처 및 근거

ORD 기록
ord-bceeb1efc46c43819dfb149a0fa8514c
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04798619

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