Sodium Bicarbonate → HCID 178512547, 화합물

HRID 2292129노트

반응식

HRID 2292129 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[O:7][CH2:8][CH2:9][S:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1.[NH:18]([C:22]1[CH:30]=[CH:29][C:25]([C:26](Cl)=[O:27])=[CH:24][CH:23]=1)[C:19]([NH2:21])=[NH:20].[C:31]([O-:34])([OH:33])=[O:32].[Na+]>N1C=CC=CC=1>[C:31](=[O:32])([OH:34])[OH:33].[NH:18]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([O:17][C:14]2[CH:13]=[CH:12][C:11]([S:10][CH2:9][CH2:8][O:7][CH:2]3[CH2:3][CH2:4][CH2:5][CH2:6][O:1]3)=[CH:16][CH:15]=2)=[O:27])=[CH:24][CH:23]=1)[C:19]([NH2:21])=[NH:20]

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 140519404-Hydroxyphenyl 2-(tetrahydropyran-2-yloxy)ethyl sulfide2회HCID 178512519HCID 178512519, 화합물

생성물 1

HCID 178512547HCID 178512547, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

96.08 g of 4-hydroxyphenyl 2-(tetrahydropyran-2-yloxy)ethyl sulfide synthesized by the above process (2) was dissolved in 800 ml of pyridine. 4-Guanidinobenzoyl chloride was added to the solution under cooling with ice and the mixture was stirred at room temperature for 24 h or longer. A saturated aqueous sodium hydrocarbonate solution was added thereto under cooling with ice and the precipitate thus obtained was recovered by filtration, washed with water, then acetone and finally ethyl acetate and dried to obtain 104 g of 4-(2-tetrahydropyran-2-yloxyethylthio)phenyl 4-guanidinobenzoate carbonate.

후처리

  1. temperatureunder cooling with ice
  2. temperatureunder cooling with ice
  3. customthe precipitate thus obtained
  4. filtrationwas recovered by filtration
  5. washwashed with water
  6. dry with materialacetone and finally ethyl acetate and dried

출처 및 근거

ORD 기록
ord-420ad075b4ae453d9cdaca7d04116add
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04801603

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