Triethylamine → 1-[[3,4-Bis(acetyloxy)benzoyl]amino]-2-imidazolidinone

HRID 2292325노트

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HRID 2292325 반응식
[NH2:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7].C(N(CC)CC)C.[C:15]([O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][C:29](=[O:31])[CH3:30])[C:22](Cl)=[O:23])(=[O:17])[CH3:16]>ClCCl>[C:15]([O:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][C:27]=1[O:28][C:29](=[O:31])[CH3:30])[C:22]([NH:1][N:2]1[CH2:6][CH2:5][NH:4][C:3]1=[O:7])=[O:23])(=[O:17])[CH3:16]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 1816971-Aminoimidazolidin-2-oneHCID 140969484-(Chlorocarbonyl)-1,2-phenylene diacetate

생성물 1

HCID 143908271-[[3,4-Bis(acetyloxy)benzoyl]amino]-2-imidazolidinone수율 99.4%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

1-Amino-2-imidazolidinone (2.61 g, 0.026 mol) was dissolved in 200 ml of dichloromethane. The solution was cooled to 0° C. and 4.1 ml of triethylamine was added, followed by 7.5 g of 3,4-bis(acetyloxy)benzoyl chloride (0.029 mol). The mixture was stirred at 0° C. for 1 hour and at room temperature for an additional hour. The precipitate was filtered off to yield 8.3 g of 1-[[3,4-bis(acetyloxy)benzoyl]amino]-2-imidazolidinone.

후처리

  1. filtrationThe precipitate was filtered off

출처 및 근거

ORD 기록
ord-8ee6a9d910904f45b81d55bdb1a4a1ca
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04801705

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