Triisopropyl borate → [2,3-Difluoro-4-(heptyloxy)phenyl]boronic acid

HRID 2292430노트

반응식

HRID 2292430 반응식
C([Li])CCC.[F:6][C:7]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:8]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21].[B:22](OC(C)C)([O:27]C(C)C)[O:23]C(C)C>>[F:13][C:12]1[C:7]([F:6])=[C:8]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:9]=[CH:10][C:11]=1[B:22]([OH:27])[OH:23]

참가 물질

4

반응물 3

HCID 21531Triisopropyl borateHCID 214779471,2-Difluoro-3-(heptyloxy)benzeneHCID 178418339Butyllithium

생성물 1

HCID 21477961[2,3-Difluoro-4-(heptyloxy)phenyl]boronic acid

실험 절차

Quantities: n-butyllithium (20 cm3, 10.0M in hexanes, 0.2 mol), compound from Example 40 (45.5 g, 0.2 mol) and triisopropyl borate (74.4 g, 0.4 mol). The experimental procedure was as described in Example 28.

출처 및 근거

ORD 기록
ord-af23ae372b474ac0926e3d034badfe5f
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05683623

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