Triisopropyl borate → (2,3-Difluoro-4-(octyloxy)phenyl)boronic acid

반응식

C([Li])CCC.[F:6][C:7]1[C:12]([F:13])=[CH:11][CH:10]=[CH:9][C:8]=1[O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22].[B:23](OC(C)C)([O:28]C(C)C)[O:24]C(C)C>>[F:13][C:12]1[C:7]([F:6])=[C:8]([O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH:9]=[CH:10][C:11]=1[B:23]([OH:28])[OH:24]

참가 물질

반응물 3

HCID 21531Triisopropyl borate

HCID 105624971,2-Difluoro-3-(octyloxy)benzene

HCID 178418339Butyllithium

생성물 1

HCID 10850744(2,3-Difluoro-4-(octyloxy)phenyl)boronic acid

실험 절차

Quantities: n-butyllithium (10 cm3, 10.0M in hexanes, 0.1 mol), compound from Example 41 (23.4 g, 0.1 mol) and triisopropyl borate (37.6 g, 0.2 mol). The experimental procedure was as described in Example 28.

출처 및 근거

ORD 기록: ord-c80776576d6a468b88619fb615e40f3f
출처 데이터셋: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05683623

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