(2,3-Difluorophenyl)boronic acid → 2-(2,3-Difluorobiphenyl-4'-yl)-5-octyl-1,3-dioxane

HRID 2292442노트

반응식

HRID 2292442 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[O:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][O:9]2)=[CH:4][CH:3]=1.[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>[F:22][C:23]1[C:28]([F:29])=[CH:27][CH:26]=[CH:25][C:24]=1[C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[O:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:10][O:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 2734333(2,3-Difluorophenyl)boronic acidHCID 129249672-(4'-Bromophenyl)-5-n-octyl-1,3-dioxane

생성물 1

HCID 214779752-(2,3-Difluorobiphenyl-4'-yl)-5-octyl-1,3-dioxane

시약·촉매·용매 2

HCID 178418397HCID 178418397, 화합물촉매HCID 10340Sodium Carbonate용매

실험 절차

Quantities: compound from Example 14 (10.7 g, 30 mmol), compound from Example 36 (5.5 g, 35 mmol), tetrakis(triphenylphosphine)palladium(0) (1.04 mg, 0.9 mmol) and aqueous sodium carbonate (30 cm3, 2M). The experimental procedure was as described in Example 63.

출처 및 근거

ORD 기록
ord-9ac42e18da964919bfa8e3fc5ce013b9
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05683623

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