1-Bromo-5-chloropentane → HCID 86181973, 화합물

HRID 2292499노트

반응식

HRID 2292499 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[Cl:10])=[CH:4][CH:3]=1.Br[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][Cl:29].[O-]CC.[Na+]>C(O)C>[Cl:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[Cl:10])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 960701-Bromo-5-chloropentaneHCID 2723922Sodium ethoxideHCID 45530804-(2-Chloro-1,2-diphenylethenyl)phenol

생성물 1

HCID 86181973HCID 86181973, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Combine (E and Z)-1-[(4-hydroxy)phenyl]-1,2-diphenyl-2-chloro-ethylene (2.3 g, 7.5 mmol) and 5-bromo-1-chloropentane (2.78 g, 15.0 mmol) in ethanol (40 mL). Add a solution of sodium ethoxide in ethanol (11.12 mL, 0.67M, 7.5 mmol). Heat to reflux under an inert atmosphere. After 24 hours concentrate in vacuo. Chromatograph on silica gel eluting with 1/7 ethyl acetate/hexane. Concentration of the product containing fractions to give the title compound which is taken on to the next step without further purification.

후처리

  1. temperatureHeat
  2. temperatureto reflux under an inert atmosphere
  3. concentrationAfter 24 hours concentrate in vacuo
  4. additionConcentration of the product containing fractions

출처 및 근거

ORD 기록
ord-48efa1ddf4f64d71a05c40a4b2c33277
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05684004

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