Ammonia → [2-(Prop-2-en-1-yloxy)phenyl]methanamine

HRID 2292590노트

반응식

HRID 2292590 반응식
[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11]Cl)[CH:2]=[CH2:3].[NH3:13]>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][NH2:13])[CH:2]=[CH2:3]

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 114580661-(Allyloxy)-2-(chloromethyl)benzene

생성물 1

HCID 14940440[2-(Prop-2-en-1-yloxy)phenyl]methanamine

실험 절차

3.0 g (16.4 mmol) of the compound from Example I are boiled under reflux for 17 hours in 250 ml of a saturated methanolic ammonia solution. The reaction mixture is evaporated in vacuo, the residue is taken up in methanol and the mixture is evaporated again; this process is repeated a few times. The crude product is taken up in dichloromethane and extracted several times with water. The aqueous phase is evaporated to a very great extent, an oil being obtained which crystallizes on standing.

후처리

  1. customThe reaction mixture is evaporated in vacuo
  2. customthe mixture is evaporated again
  3. extractionextracted several times with water
  4. customThe aqueous phase is evaporated to a very great extent
  5. customan oil being obtained which
  6. customcrystallizes on standing

출처 및 근거

ORD 기록
ord-e77beb90fa3949228b296932d8ee6669
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05684014

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