Phenethylamine → 1-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

반응식

[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:10][C:11]([F:16])([F:15])[C:12](O)=O>>[F:10][C:11]([F:16])([F:15])[CH:12]1[C:8]2[C:3](=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:2][CH2:1][NH:9]1

참가 물질

반응물 2

HCID 1001Phenethylamine

HCID 6422Trifluoroacetic acid

생성물 1

HCID 214764331-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline

실험 절차

In accordance with the same procedures as in Preparation 1-1, except that 25 ml of phenethylamine(0.2M) and 30 ml of anhydrous trifluoroacetic acid(0.21M) were used as starting materials, 5.4 g of the title compound was prepared.

후처리

customIn accordance with the same procedures as in Preparation 1-1

출처 및 근거

ORD 기록: ord-ab1c1ac0229842e992968e8bb7a17d5b
출처 데이터셋: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05686458

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