4-Fluoro-2-methylaniline → HCID 21476493, 화합물

HRID 2293165노트

반응식

HRID 2293165 반응식
[Cl:1][C:2]1[N:11]=[C:10]([N:12]2[CH:21]([CH3:22])[CH2:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13]2)[C:9]2[C:4](=[C:5]([O:23][CH3:24])[CH:6]=[CH:7][CH:8]=2)[N:3]=1.[F:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[C:28]([CH3:33])[CH:27]=1>CN(C)C=O>[ClH:1].[F:25][C:26]1[CH:32]=[CH:31][C:29]([NH:30][C:2]2[N:11]=[C:10]([N:12]3[CH:21]([CH3:22])[CH2:20][C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH2:13]3)[C:9]3[C:4](=[C:5]([O:23][CH3:24])[CH:6]=[CH:7][CH:8]=3)[N:3]=2)=[C:28]([CH3:33])[CH:27]=1

참가 물질

4

반응물 2

HCID 679824-Fluoro-2-methylanilineHCID 21476491HCID 21476491, 화합물

생성물 1

HCID 21476493HCID 21476493, 화합물수율 29%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In accordance with the same procedures as in Example 18, except that to a mixture of 2.0 g of the compound (5.9 mM) prepared in Example 12 and 15 ml of dimethyl-formamide, 1.1 ml of 4-fluoro-2-methylaniline(8.9 mM) was added, 0.8 g of the title compound was prepared.

후처리

  1. additionwas added

출처 및 근거

ORD 기록
ord-007ba697864449098b51752b6d2ef4bc
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05686458

반응 노트

불러오는 중…