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HCID 67619423, 화합물 → L-isoleucine, N-[1-(carboxymethyl)-L-prolyl] benzylamide

HRID 2293393
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HRID 2293393 반응식
C([O:8][C:9](=[O:34])[CH2:10][N:11]1[CH2:33][CH2:32][CH2:31][C@H:12]1[C:13]([N:15]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:16](=[O:23])[C@H:17]([C@H:19]([CH2:21][CH3:22])[CH3:20])[NH2:18])=[O:14])C1C=CC=CC=1.[H][H]>[Pd].CO>[C:9]([CH2:10][N:11]1[CH2:33][CH2:32][CH2:31][C@H:12]1[C:13]([N:15]([CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:16](=[O:23])[C@H:17]([C@H:19]([CH2:21][CH3:22])[CH3:20])[NH2:18])=[O:14])([OH:34])=[O:8]
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참가 물질

5

반응물 2

HCID 67619423HCID 67619423, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 131720284L-isoleucine, N-[1-(carboxymethyl)-L-prolyl] benzylamide수율 96%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

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온도
22 °C

실험 절차

Using the hydrogenation conditions described in example 4, a solution of L-isoleucine, N-[1-(2-benzyloxy-2-oxoethyl)-L-prolyl] benzylamide (14.80 g, 31.76 mmol), 10% palladium on carbon (0.80 g), and methanol (350 mL), was purged with hydrogen, and stirred under an atmosphere of hydrogen at 22° C. After 8 hrs, the solution was purged with argon, filtered through a plug of celite, and concentrated in vacuo to provide 11.47 g, (96%) of L-isoleucine, N-[1-(carboxymethyl)-L-prolyl] benzylamide as a white solid.

후처리

  1. customthe solution was purged with argon
  2. filtrationfiltered through a plug of celite
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-9351814a98f049e6a400fbe1137ee82e
출처 데이터셋
uspto-grants-1997_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05686424

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