Acetone → HCID 21476885, 화합물

반응식

[CH3:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[O:4][CH2:5][CH:6]1[O:10][C:9]([NH2:11])=[N:8][CH2:7]1.[CH3:16][C:17]([CH3:19])=O>>[CH2:16]([NH:11][C:9]1[O:10][CH:6]([CH2:5][O:4][C:3]2[CH:12]=[CH:13][CH:14]=[CH:15][C:2]=2[CH3:1])[CH2:7][N:8]=1)[CH2:17][CH3:19]

참가 물질

반응물 2

HCID 180Acetone

HCID 10176633169137-04-6

생성물 1

HCID 21476885HCID 21476885, 화합물

실험 절차

In a reactor are introduced 0,01 mol of 5-[(2-methylphenoxy)methyl]-4,5-dihydro-oxazol-2-ylamine and 100 ml of acetone. Once dissolution is complete, 0,005 mol of 1-bromopropyl are added and the whole is heated to ebullition during 48 hours. After filtering off the formed solid and evaporating the solvent, the crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5).

후처리

dissolutionOnce dissolution
addition0,005 mol of 1-bromopropyl are added
temperaturethe whole is heated
filtrationAfter filtering off the formed solid
customevaporating the solvent
customthe crude desired product is purified by separation by column chromatography (eluent: chloroform/ammonia, 95:5)

출처 및 근거

ORD 기록: ord-78e30df230a6459abf46e947c99ac0f8
출처 데이터셋: uspto-grants-1997_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05686477

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