Cyclopropyl(3-nitrophenyl)methanone → (3-Aminophenyl)(cyclopropyl)methanone
반응식
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-])=O)[CH:7]=2)=[O:5])[CH2:3][CH2:2]1.[H][H]>[Pd].CO>[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([NH2:12])[CH:7]=2)=[O:5])[CH2:2][CH2:3]1참가 물질
5
실험 절차
A Parr hydrogenation tube is charged with palladium on carbon (0.030 g). cyclopropyl-(3-nitrophenyl)methanone of Preparation 45 (0.250 g) and 10 mL of methanol. The tube is shaken at room temperature under 40 psi of hydrogen overnight. The reaction mixture is then filtered through Celite and concentrated to give 0.207 g of the title product which is used without further purification.
후처리
- filtrationThe reaction mixture is then filtered through Celite
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-306fdae43ae840b48afe80ec6a50af2d
- 출처 데이터셋
- uspto-grants-1997_11
- 특허 번호
- US05686486
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