2-(4-fluorophenyl)-1-phenylethanone → HCID 54455826, 화합물

HRID 2293969노트

반응식

HRID 2293969 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)=[CH:4][CH:3]=1.Cl.[O:18]([NH2:20])[CH3:19]>N1C=CC=CC=1>[CH3:19][O:18][N:20]=[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=1

참가 물질

4

반응물 2

HCID 2363292-(4-fluorophenyl)-1-phenylethanoneHCID 521874O-Methylhydroxylamine hydrochloride

생성물 1

HCID 54455826HCID 54455826, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
25 °C

실험 절차

To a solution of 2-(4-fluorophenyl)-1-phenyl-1-ethanone (5 g, 30 mmol) in 30 ml pyridine under nitrogen was added methoxylamine hydrochloride (3.8 g, 45 mmol) at 25° C. The resulting mixture was stirred at 25° C. for 17 hours. The pyridine was removed in vacuo with heating. The residual solids were a mixture of the oxime geometrical isomers as a white syrup and it was used for the next step without further purification. Rf : 0.48, 0.70 (CH2C12).

후처리

  1. customThe pyridine was removed in vacuo
  2. temperaturewith heating
  3. additiona mixture of the oxime geometrical isomers as a white syrup and it
  4. customwas used for the next step without further purification

출처 및 근거

ORD 기록
ord-a5c4beae8db24ec0b2df607fd6a23ebe
출처 데이터셋
uspto-grants-1997_11
특허 번호
US05688789

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